The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

An international panel of experts prepared an evidenced-based guideline for vaccination of
immunocompromised adults and children. These guidelines are intended for use by primary …

The global diversity of fungi has been estimated between 2 to 11 million species, of which
only about 155 000 have been named. Most fungi are invisible to the unaided eye, but they …

Fungi are an understudied resource possessing huge potential for developing products that
can greatly improve human well-being. In the current paper, we highlight some important …

Caspase recruitment-domain containing protein 9 (CARD9) is a key signaling pathway in
macrophages but its role in atherosclerosis is still poorly understood. Global deletion of …

This paper reviews the developments that have occurred in the field of human genetics of
infectious diseases from the second half of the 20th century onward. In particular, it stresses …

In the last few decades, the AIDS pandemic and the significant advances in the medical
management of individuals with neoplastic and inflammatory conditions have resulted in a …

Background & aims Monogenic forms of inflammatory bowel disease (IBD) illustrate the
essential roles of individual genes in pathways and networks safeguarding immune …

Mendelian susceptibility to mycobacterial diseases confers predisposition to clinical disease
caused by weakly virulent mycobacterial species in otherwise healthy individuals. Since …