Solid-state nuclear magnetic resonance (NMR) spectroscopy is an atomic-level method to
determine the chemical structure, 3D structure and dynamics of solids and semi-solids. This …

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol
(Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid …

Amyloid proteins are involved in many neurodegenerative disorders such as Alzheimer's
disease [Tau, Amyloid β (Aβ)], Parkinson's disease [alpha-synuclein (αSyn)], and …

The presence of amyloid plaques in the brain is a typical characteristic of Alzheimer's
disease (AD). Amyloid plaques are formed from the deposits of aggregated amyloid β …

Solid-state nuclear magnetic resonance (SSNMR) spectroscopy elucidates membrane
protein structures and dynamics in atomic detail to yield mechanistic insights. By …

Disruption of the neuronal membrane by toxic amyloid β oligomers is hypothesized to be the
major event associated with Alzheimer's disease's neurotoxicity. Misfolding of amyloid β is …

Molecular interactions between β-amyloid (Aβ) peptide and membranes contribute to the
neuronal toxicity of Aβ and the pathology of Alzheimer's disease. Neuronal plasma …

Identifying the structures of membrane bound proteins is critical to understanding their
function in healthy and diseased states. We introduce a surface enhanced Raman …

Amyloid formation continues to be a widely studied area due to its association with
numerous diseases, such as Alzheimer's and Parkinson's diseases. Despite a large body of …

The aggregation of proteins and peptides into a variety of insoluble, and often non-native,
aggregated states plays a central role in many devastating diseases. Analogous processes …