Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings)

G Mion, T Villevieille - CNS neuroscience & therapeutics, 2013 - Wiley Online Library
For more than 50 years, ketamine has proven to be a safe anesthetic drug with potent
analgesic properties. The active enantiomer is S (+)‐ketamine. Ketamine is mostly …

Abnormal neural oscillations and synchrony in schizophrenia

PJ Uhlhaas, W Singer - Nature reviews neuroscience, 2010 - nature.com
Converging evidence from electrophysiological, physiological and anatomical studies
suggests that abnormalities in the synchronized oscillatory activity of neurons may have a …

Brain NMDA receptors in schizophrenia and depression

A Adell - Biomolecules, 2020 - mdpi.com
N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …

Neuronal dynamics and neuropsychiatric disorders: toward a translational paradigm for dysfunctional large-scale networks

PJ Uhlhaas, W Singer - Neuron, 2012 - cell.com
In recent years, numerous studies have tested the relevance of neural oscillations in
neuropsychiatric conditions, highlighting the potential role of changes in temporal …

Human auditory steady-state responses: Respuestas auditivas de estado estable en humanos

TW Picton, MS John, A Dimitrijevic… - International journal of …, 2003 - Taylor & Francis
Steady-state evoked potentials can be recorded from the human scalp in response to
auditory stimuli presented at rates between 1 and 200 Hz or by periodic modulations of the …

Reviewing the ketamine model for schizophrenia

J Frohlich, JD Van Horn - Journal of psychopharmacology, 2014 - journals.sagepub.com
The observation that antagonists of the N-methyl-D-aspartate receptor (NMDAR), such as
phencyclidine (PCP) and ketamine, transiently induce symptoms of acute schizophrenia had …

A review of the nonmedical use of ketamine: use, users and consequences

KLR Jansen - Journal of psychoactive drugs, 2000 - Taylor & Francis
Ketamine is a dissociative anesthetic with an accepted place in human medicine. Ketamine
also has psychedelic properties, and there has been a recent increase in nonmedical use …

Gamma and delta neural oscillations and association with clinical symptoms under subanesthetic ketamine

LE Hong, A Summerfelt, RW Buchanan… - …, 2010 - nature.com
Several electrical neural oscillatory abnormalities have been associated with schizophrenia,
although the underlying mechanisms of these oscillatory problems are unclear. Animal …

The auditory steady-state response (ASSR): a translational biomarker for schizophrenia

BF O'Donnell, JL Vohs, GP Krishnan, O Rass… - Supplements to Clinical …, 2013 - Elsevier
Electrophysiological methods have demonstrated disturbances of neural synchrony and
oscillations in schizophrenia which affect a broad range of sensory and cognitive processes …

Ketamine-induced hallucinations

AR Powers III, MG Gancsos, ES Finn, PT Morgan… - …, 2015 - karger.com
Background: Ketamine, the NMDA glutamate receptor antagonist drug, is increasingly
employed as an experimental model of psychosis in healthy volunteers. At subanesthetic …