Nuclear pore complexes (NPCs) are multiprotein aqueous channels that penetrate the
nuclear envelope connecting the nucleus and the cytoplasm. NPCs consist of multiple …

The study of the Nuclear Pore Complex (NPC), the proteins that compose it (nucleoporins),
and the nucleocytoplasmic transport that it controls have revealed an unexpected layer to …

Human 'laminopathy'diseases result from mutations in genes encoding nuclear lamins or
nuclear envelope (NE) transmembrane proteins (NETs). These diseases present a seeming …

Pluripotent stem cells, which include embryonic stem cells and induced pluripotent stem
cells, use a complex network of genetic and epigenetic pathways to maintain a delicate …

Nuclear pore complexes (NPCs) are the only gateways between the nucleus and cytoplasm
in eukaryotic cells. They restrict free diffusion to molecules below 5 nm while facilitating the …

Ran Binding Protein 2 (RanBP2 or Nucleoporin358) is one of the main components of the
cytoplasmic filaments of the nuclear pore complex. Mutations in the RANBP2 gene are …

Nucleocytoplasmic transport is an essential cellular activity and occurs via nuclear pore
complexes (NPCs) that reside in the double membrane of the nuclear envelope. Significant …

Nuclear pore complexes are multiprotein channels that span the nuclear envelope, which
connects the nucleus to the cytoplasm. In addition to their main role in the regulation of …

Galectin-3, a member of β-galactoside-binding gene family is a multi-functional protein,
which regulates pleiotropic biological functions such as cell growth, cell adhesion, cell–cell …

O-glycosylation of the nuclear pore complex (NPC) by O-linked N-acetylglucosamine (O-
GlcNAc) is conserved within metazoans. Many nucleoporins (Nups) comprising the NPC are …