As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of
cellular processes, including those involving vascular cells. This brief review summarizes …

Cardiovascular disease (CVD) is the leading cause of death in the United States and aging
is a major risk factor for CVD development. One of the major age-related arterial phenotypes …

Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a
healthy cardiovascular system. The importance of eNOS can be emphasized from the …

Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome
P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20 …

Reactive oxygen and nitrogen species are produced in a wide range of physiological
reactions that, at low concentrations, play essential roles in living organisms. There is a …

Nitric oxide (NO) physiologically stimulates the sarco/endoplasmic reticulum calcium (Ca2+)
ATPase (SERCA) to decrease intracellular Ca2+ concentration and relax cardiac, skeletal …

The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also
by other pathways causing hyperpolarization of the underlying smooth muscle cells. This …

The endothelium controls vascular tone not only by releasing nitric oxide (NO) and
prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth …

Connexins have been hypothesized to play an important role in intercellular communication
within the vascular wall and may provide a mechanistic explanation for conduction of …

Background—Flow-induced vasodilation (FID) is a physiological mechanism for regulating
coronary flow and is mediated largely by nitric oxide (NO) in animals. Because …