Polymeric biomaterials: Advanced drug delivery systems in osteoarthritis treatment

L Liu, H Tang, Y Wang - Heliyon, 2023 - cell.com
Polymeric biomaterials have emerged as a highly promising candidate for drug delivery
systems (DDS), exhibiting significant potential to enhance the therapeutic landscape of …

The biomedical applications of nanozymes in orthopaedics based on regulating reactive oxygen species

X Gao, J Zhang, Y Gong, L Yan - Journal of Nanobiotechnology, 2024 - Springer
Nanozymes, a category of nanomaterials with enzyme-like activity, have garnered growing
interest in various biomedical contexts. Notably, nanozymes that are capable of regulating …

[HTML][HTML] Novel molecule BBC0901 inhibits BRD4 and acts as a catabolic regulator in the pathogenesis of osteoarthritis

H Lee, J Nam, H Jang, YS Park, MH Son, IH Lee… - Biomedicine & …, 2023 - Elsevier
Osteoarthritis (OA) is induced by matrix degradation and inflammation mediated by bromo-
domain-containing protein 4 (BRD4)-dependent catabolic factors. BRD4 acts as both a …

[HTML][HTML] Dual-sided centripetal microgrooved poly (D, L-lactide-co-caprolactone) disk encased in immune-regulating hydrogels for enhanced bone regeneration

Y Wu, X Yue, Y Zhang, N Yu, C Ge, R Liu, Z Duan… - Materials Today Bio, 2025 - Elsevier
Well-designed artificial scaffolds are urgently needed due to the limited self-repair capacity
of bone, which hampers effective regeneration in critical defects. Optimal scaffolds must …

Microenvironment-Sensitive Nanozymes for Tissue Regeneration

Y Xiong, B Mi, G Liu, Y Zhao - Biomaterials, 2024 - Elsevier
Tissue defect is one of the significant challenges encountered in clinical practice.
Nanomaterials, including nanoparticles, nanofibers, and metal-organic frameworks, have …

Nanoenzyme-Anchored Mitofactories Boost Mitochondrial Transplantation to Restore Locomotor Function after Paralysis Following Spinal Cord Injury

R Wei, Y Chen, Q Yang, T Wang, Y He, N Yin, L Yang… - ACS …, 2025 - ACS Publications
Mitochondrial transplantation is a significant therapeutic approach for addressing
mitochondrial dysfunction in patients with spinal cord injury (SCI), yet it is limited by rapid …

Nanozyme-based therapeutic strategies for rheumatoid arthritis

J Zhang, C Wang, X Wu, Q Shen, Y Du - Journal of Controlled Release, 2025 - Elsevier
Rheumatoid arthritis (RA) is a prevalent chronic autoimmune disease that leads to severe
joint damage and disability. Conventional treatment options are limited by their efficacy and …

Nano-enzyme hydrogels for cartilage repair effectiveness based on ternary strategy therapy

W Deng, Y Zhou, Q Wan, L Li, H Deng, Y Yin… - Journal of Materials …, 2024 - pubs.rsc.org
Designing artificial nano-enzymes for scavenging reactive oxygen species (ROS) in
chondrocytes (CHOs) is considered the most feasible pathway for the treatment of …

Chemically programmed nanozyme with microenvironment remodeling for combinatorial treatment of osteoarthritis

J Guo, C Li, J Lin, J Fang, Y Sun, P Zhang, S Li… - Chemical Engineering …, 2024 - Elsevier
Restoring the equilibrium of joint homeostasis is crucial in treating osteoarthritis (OA).
However, current strategies are primarily concentrated on individual interventions aimed at …

A novel prussian blue/polyaniline composite gas sensor for fast detection of ammonia

I da Luz Rodrigues, GS Correia, CC dos Santos… - Materials Letters, 2024 - Elsevier
This study aims reporting the development of a gas sensor composite whose phases are
Prussian blue (PB) and polyaniline (PANI). Structural characterization techniques confirmed …