Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Degradable and recyclable polymers by reversible deactivation radical polymerization

MR Martinez, K Matyjaszewski - CCS Chemistry, 2022 - chinesechemsoc.org
Reversible deactivation radical polymerization (RDRP) provides unprecedented control over
polymer composition, size, functionality, and topology. Various materials, such as linear …

One-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer delivery systems for mRNA

D Zhang, EN Atochina-Vasserman… - Journal of the …, 2021 - ACS Publications
Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine.
Both viral and synthetic vectors have been successfully employed for genetic delivery with …

RNA-polymer hybrids via direct and site-selective acylation with the ATRP initiator and photoinduced polymerization

J Jeong, X Hu, H Murata, G Szczepaniak… - Journal of the …, 2023 - ACS Publications
Combining synthetic polymers with RNA paves the way for creating RNA-based materials
with non-canonical functions. We have developed an acylation reagent that allows for direct …

[HTML][HTML] Polymer bioconjugates: Modern design concepts toward precision hybrid materials

C Chen, DYW Ng, T Weil - Progress in Polymer Science, 2020 - Elsevier
The conjugation of synthetic polymers with various biomolecules provides an easy access to
biohybrid materials which combine advantages from both the synthetic world and Nature …

Degradable vinyl polymers for biomedical applications

V Delplace, J Nicolas - Nature chemistry, 2015 - nature.com
Vinyl polymers have been the focus of intensive research over the past few decades and are
attractive materials owing to their ease of synthesis and their broad diversity of architectures …

Bioapplications of RAFT polymerization

C Boyer, V Bulmus, TP Davis, V Ladmiral, J Liu… - Chemical …, 2009 - ACS Publications
A living radical polymerization (LRP) is a free radical polymerization that aims at displaying
living character,(ie, does not terminate or transfer and is able to continue polymerization …

Living radical polymerization by the RAFT process–a second update

G Moad, E Rizzardo, SH Thang - Australian journal of chemistry, 2009 - CSIRO Publishing
This paper provides a second update to the review of reversible deactivation radical
polymerization achieved with thiocarbonylthio compounds (ZC (= S) SR) by a mechanism of …

Telechelic polymers by living and controlled/living polymerization methods

MA Tasdelen, MU Kahveci, Y Yagci - Progress in Polymer Science, 2011 - Elsevier
Telechelic polymers, defined as macromolecules that contain two reactive end groups, are
used as cross-linkers, chain extenders, and important building blocks for various …

Temperature-regulated activity of responsive polymer− protein conjugates prepared by grafting-from via RAFT polymerization

P De, M Li, SR Gondi, BS Sumerlin - Journal of the American …, 2008 - ACS Publications
A facile route to well-defined “smart” polymer− protein conjugates with tunable bioactivity is
reported. Protein modification with a reversible addition− fragmentation chain transfer …