Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

Research in recent years has focused significantly on the role of selective macroautophagy
in targeting intracellular pathogens for lysosomal degradation, a process termed xenophagy …

Autophagy is a fundamental and highly conserved eukaryotic process, responsible for
maintaining cellular homeostasis and releasing nutrients during times of starvation. An …

The Q fever bacterium Coxiella burnetii replicates inside host cells within a large Coxiella-
containing vacuole (CCV) whose biogenesis relies on the Dot/Icm-dependent secretion of …

Invasion of macrophages and replication within an acidic and degradative phagolysosome-
like vacuole are essential for disease pathogenesis by Coxiella burnetii, the bacterial agent …

The ability to genetically manipulate a pathogen is fundamental to discovering factors
governing host–pathogen interactions at the molecular level and is critical for devising …

Coxiella burnetii is an intracellular bacterium that causes acute and chronic Q fever. This
unique pathogen has been historically challenging to study due to obstacles in genetically …

Intracellular bacteria have developed numerous strategies to hijack host vesicular trafficking
pathways to form their unique replicative niches. To promote intracellular replication, the …

Host cell-free (axenic) culture of Coxiella burnetii in acidified citrate cysteine medium-2
(ACCM-2) has provided important opportunities for investigating the biology of this naturally …

Coxiella burnetii, the etiologic agent of Q fever, is a Gram-negative obligate intracellular
bacterium. It has been previously described that both the endocytic and autophagic …