Efficient S phase entry is essential for development, tissue repair, and immune defences.
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …

RING E3s comprise the largest family of ubiquitin (UB) and ubiquitin-like protein (UBL)
ligases. RING E3s typically promote UB or UBL transfer from the active site of an associated …

Ubiquitylation is catalyzed by coordinated actions of E3 and E2 enzymes. Molecular
principles governing many important E3-E2 partnerships remain unknown, including those …

The diabetes-cancer association remains underexplained. Here, we describe a glucose-
signaling axis that reinforces glucose uptake and glycolysis to consolidate the Warburg …

In the cellular response to stresses, the tumor suppressor p53 is activated to maintain
genomic integrity and fidelity. As a transcription factor, p53 exhibits rich dynamics to allow for …

Most well studied as proteins that restrain the p53 tumor suppressor protein, MDM2 and
MDMX have rich lives outside of their relationship to p53. There is much to learn about how …

Summary Mind bomb 1 (MIB1) is a RING E3 ligase that ubiquitinates Notch ligands, a
necessary step for induction of Notch signaling. The structural basis for binding of the JAG1 …

Reversible phosphorylation is a fundamental mechanism for controlling protein function.
Despite the critical roles phosphorylated proteins play in physiology and disease, our ability …

Tumour necrosis factor (TNF) receptor associated factor (TRAF) family members share a
common domain architecture, but play non-redundant physiological roles in cell signalling …

Inflammation is essential for healthy immune function, wound healing, and resolution of
infection. RIG-I is a key RNA sensor that initiates an immune response, with activation and …