Liquid chromatography (LC) based techniques in combination with mass spectrometry (MS)
detection have had a large impact on the development of new pharmaceuticals in the past …

Hydroxynorketamines (HNKs) are formed in vivo after (R, S)-ketamine (ketamine)
administration. The 12 HNK stereoisomers are distinguished by the position of cyclohexyl …

Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, has revolutionized the
treatment of depression because of its potent, rapid and sustained antidepressant effects …

The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine has attracted enormous
interest in mental health research owing to its rapid antidepressant actions, but its …

In recent years, major attention has been focused on microextraction procedures that allow
high recovery of target analytes, regardless of the complexity of the sample matrices. The …

In this study, we designed a rapid colorimetric sensing system using competitive ELISA test
on a microfluidic paper-based analytical device for the detection of ketamine, a frequently …

On-line solid-phase supercritical fluid extraction (SFE) and chromatography (SFC) coupled
to mass spectrometry (MS) has been evaluated for its usefulness with respect to metabolic …

Ketamine shows promise as a rapidly-acting treatment for depression and suicidal ideation,
but side effects and abuse potential limit its use. Understanding its mechanism of action …

Abstract Ketamine (Ket) and midazolam (Mdz) are among well-known anesthetic agents
which frequently coadministered in surgical procedures and emergency department. Only a …

Since the metabolism of (R, S)-ketamine to (2 R, 6 R)-hydroxynorketamine (HNK) is reported
to be essential for ketamine's antidepressant effects, there is an increasing debate about …