Abstract Sphingosine 1-phosphate receptor (S1PR), as a kind of G protein-coupled receptor,
has five subtypes, including S1PR1, S1PR2, S1PR3, S1PR4, and S1PR5. Sphingosine 1 …

G-protein-coupled receptors (GPCRs) constitute a prominent superfamily in humans and are
categorized into six classes (A–F) that play indispensable roles in cellular communication …

Abstract Somatostatin receptor 2 (SSTR2) is highly expressed in neuroendocrine tumors
and represents as a therapeutic target. Several peptide analogs mimicking the endogenous …

The activation of Sphingosine-1-phosphate receptor 1 (S1PR1) by S1P promotes
lymphocyte egress from lymphoid organs, a process critical for immune surveillance and T …

GPR84 is a unique orphan G protein-coupled receptor (GPCR) that can be activated by
endogenous medium-chain fatty acids (MCFAs). The signaling of GPR84 is largely pro …

Adhesion G protein-coupled receptors (aGPCRs) are evolutionarily ancient receptors
involved in a variety of physiological and pathophysiological processes. Modulators of …

Abstract The ten Frizzled receptors (FZDs) are essential in Wnt signaling and play important
roles in embryonic development and tumorigenesis. Among these, FZD6 is closely …

Sphingosine-1-phosphate (S1P) is an important sphingolipid molecule involved in
regulating cardiovascular functions in physiological and pathological conditions by binding …

Lysophosphatidylserine (LysoPS) is a naturally occurring lipid mediator involved in various
physiological and pathological processes especially those related to the immune system …

One hundred and fifty years ago, Johann Thudichum described sphingolipids as unusual
“Sphinx-like” lipids from the brain. Today, we know that thousands of sphingolipid molecules …