Protein phosphorylation is an important post‐transcriptional modification involving an
extremely wide range of intracellular signaling transduction pathways, making it an …

Urologic cancers such as kidney, bladder, prostate, and uroepithelial cancers have recently
become a considerable global health burden, and the response to immunotherapy is limited …

Acute myeloid leukemia (AML) is characterized by arrested differentiation making
differentiation therapy a promising treatment strategy. Recent success of inhibitors of …

CPX-351, a liposomal combination of cytarabine plus daunorubicin, has been approved for
the treatment of adults with newly diagnosed, therapy-related acute myeloid leukemia (AML) …

Targeting kinase activity is considered to be an attractive therapeutic strategy to overcome
acute myeloid leukemia (AML) since aberrant activation of the kinase pathway plays a …

The combined influence of oncogenic drivers, genomic instability, and/or DNA damage
repair deficiencies increases replication stress in cancer. Cells with high replication stress …

Progress in cancer therapy changed the outcome of many patients and moved therapy from
chemotherapy agents to targeted drugs. Targeted drugs already changed the clinical …

Despite several new therapeutic options for acute myeloid leukemia (AML), disease relapse
remains a significant challenge. We have previously demonstrated that augmenting …

Splicing factors are frequently mutated in myelodysplastic syndromes (MDS) and acute
myeloid leukemia (AML). These mutations are presumed to contribute to oncogenic …

Acute myeloid leukemia (AML) is characterized by arrested differentiation making
differentiation therapy a promising treatment strategy. Recent success of inhibitors of …