The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

The understanding, diagnosis, and treatment of retinopathy of prematurity have changed in
the 70 years since the original description of retrolental fibroplasia associated with high …

Reactive oxygen species (ROS) normally play an important physiological role in health
regulating cellular processes and signal transduction. The amount of ROS is usually kept in …

During the perinatal period, free radicals (FRs) are involved in several physiological roles
such as the cellular responses to noxia, the defense against infectious agents, the regulation …

Proliferative diabetic retinopathy (PDR) is the most severe form of diabetic retinopathy and,
along with diabetic macular edema, is responsible for the majority of blindness in adults …

Ischemic retinopathies, such as diabetic retinopathy (DR), retinopathy of prematurity and
retinal vein occlusion are a major cause of blindness in developed nations worldwide. Each …

We have recently found that diabetes-induced premature senescence of retinal endothelial
cells is accompanied by NOX2-NADPH oxidase-induced increases in the ureohydrolase …

The lack of effective therapies to limit neurovascular injury in ischemic retinopathy is a major
clinical problem. This study aimed to examine the role of ureohydrolase enzyme, arginase 1 …

Purpose: Advances in mass spectrometry have provided new insights into the role of
metabolomics in the etiology of several diseases. Studies on retinopathy of prematurity …