Therapeutic implications of ferroptosis in renal fibrosis

Y Zhang, Y Mou, J Zhang, C Suo, H Zhou… - Frontiers in Molecular …, 2022 - frontiersin.org
Renal fibrosis is a common feature of chronic kidney disease (CKD), and can lead to the
destruction of normal renal structure and loss of kidney function. Little progress has been …

Renoprotective effects of DPP-4 inhibitors

D Kawanami, Y Takashi, H Takahashi, R Motonaga… - Antioxidants, 2021 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD)
worldwide. Dipeptidyl peptidase (DPP)-4 inhibitors are widely used in the treatment of …

Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKCβ/p66Shc axis and activation of FOXO-3a

JZ ALTamimi, NA AlFaris, AM Al-Farga… - The Journal of nutritional …, 2021 - Elsevier
This study investigated if the nephroprotective effect of Curcumin in streptozotocin-induced
type 1 diabetes mellitus (DM) in rats involves downregulation/inhibition of p 66 Shc and …

BM-MSCs alleviate diabetic nephropathy in male rats by regulating ER stress, oxidative stress, inflammation, and apoptotic pathways

T Khamis, A Abdelkhalek, H Abdellatif… - Frontiers in …, 2023 - frontiersin.org
Introduction: Diabetic nephropathy (DN), a chronic kidney disease, is a major cause of end-
stage kidney disease worldwide. Mesenchymal stem cells (MSCs) have become a …

SGLT2 inhibitors attenuate nephrin loss and enhance TGF-β1 secretion in type 2 diabetes patients with albuminuria: a randomized clinical trial

Y Tian, X Chen, X Liang, X Wu, C Yao - Scientific Reports, 2022 - nature.com
To evaluate the effect of SGLT2 inhibitor (SGLT2i) on albuminuria, nephrin (NPH) and
transforming-growth-factor-beta1 (TGF-β1) levels in urine and low-grade inflammation in …

Dendrobium mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway

Y Chen, YF Zheng, XH Lin… - Molecular …, 2021 - spandidos-publications.com
Dendrobium mixture (DMix) is a Traditional Chinese Medicine widely used for preventing
and treating diabetic nephropathy (DN). Autophagy contributes to DN development and …

The Protective Effects of Curcumin against Renal Toxicity

J Zhai, Z Chen, Q Zhu, Z Guo, N Wang… - Current Medicinal …, 2024 - benthamdirect.com
Curcumin is a naturally polyphenolic compound used for hepatoprotective,
thrombosuppressive, neuroprotective, cardioprotective, antineoplastic, antiproliferative …

Diabetes mellitus therapy in the light of oxidative stress and cardiovascular complications

AAM Osman, A Seres-Bokor, E Ducza - Journal of Diabetes and its …, 2024 - Elsevier
Type 2 diabetes is a chronic disease requiring comprehensive pharmacological and non-
pharmacological interventions to slow its progression and prevent or delay its micro-and …

Linagliptin ameliorates tacrolimus-induced renal injury: role of Nrf2/HO-1 and HIF-1α/CTGF/PAI-1

ME Nady, OMA El-Raouf, ESM El-Sayed - Molecular Biology Reports, 2024 - Springer
Background Tacrolimus (TAC) is a frequently used immunosuppressive medication in organ
transplantation. However, its nephrotoxic impact limits its long-term usage. This study aims …

[HTML][HTML] Evaluation of the Effect of an α-Adrenergic Blocker, a PPAR-γ Receptor Agonist, and a Glycemic Regulator on Chronic Kidney Disease in Diabetic Rats

J Morones, M Pérez, M Muñoz, E Sánchez… - International Journal of …, 2024 - mdpi.com
Diabetic nephropathy (DN) is a globally widespread complication of diabetes mellitus (DM).
Research indicates that pioglitazone and linagliptin mitigate the risk of DN by reducing …