Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …

Organoid models of early tissue development have been produced for the intestine, brain,
kidney and other organs, but similar approaches for the heart have been lacking. Here we …

Generation of pancreatic β cells from human pluripotent stem cells (hPSCs) holds promise
as a cell replacement therapy for diabetes. In this study, we establish a link between the …

Background & Aims There are few in vitro models for studying the 3-dimensional interactions
among different liver cell types during organogenesis or disease development. We aimed to …

Background Association of chromatin with lamin proteins at the nuclear periphery has
emerged as a potential mechanism to coordinate cell type-specific gene expression and …

The liver has the ability to repair itself after injury; however, a variety of pathological changes
in the liver can affect its ability to regenerate, and this could lead to liver failure …

Organoids have immense potential as ex vivo disease models for drug discovery and
personalized drug screening. Dynamic changes in individual organoid morphology, number …

Cost-effective treatment strategies for liver fibrosis or cirrhosis are limited. Many clinical trials
of stem cells for liver disease shown that stem cells might be a potential therapeutic …

Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models
of human tissue development but display immature phenotypes, aberrant tissue fates, and a …