The DNA-dependent RNA polymerase core enzyme in Gram-positive bacteria consists of
seven subunits. Whilst four of them (α2ββ′) are essential, three smaller subunits, δ, ɛ and …

In Staphylococcus aureus, hundreds of small regulatory or small RNAs (sRNAs) have been
identified, yet this class of molecule remains poorly understood and severely understudied …

Bacterial RNAP needs to form holoenzyme with σ factors to initiate transcription. While
Staphylococcus aureus σA controls housekeeping functions, S. aureus σB regulates …

Staphylococcus aureus is an important clinical bacterium prevalent in human-associated
microbiomes and the cause of many diseases. However, S. aureus has been intractable to …

The ability of Staphylococcus aureus to resist host innate immunity augments the severity
and pervasiveness of its pathogenesis. Nitric oxide (NO˙) is an innate immune radical that is …

Background Bacteria rely on efficient gene regulatory mechanisms to switch between
genetic programs when they are facing new environments. Although this regulation can …

Staphylococcus aureus is a major human pathogen that causes infection in a wide variety of
sites within the human body. Its ability to adapt to the human host and to produce a …

Nitric oxide (NO) is emerging as an important regulator of bacterial stress resistance, biofilm
development, and virulence. One potential source of endogenous NO production in the …

Staphylococcus aureus is a versatile pathogen of humans and a continued public health
concern due to the rise and spread of multidrug-resistant strains. As part of an ongoing …

Pseudomonas plecoglossicida, a temperature dependent bacterial pathogen in fish,
expresses rpoE gene that is sensitive to temperature and probably critical for pathogen …