[HTML][HTML] Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
[HTML][HTML] Metformin and the gastrointestinal tract
LJ McCreight, CJ Bailey, ER Pearson - Diabetologia, 2016 - Springer
Metformin is an effective agent with a good safety profile that is widely used as a first-line
treatment for type 2 diabetes, yet its mechanisms of action and variability in terms of efficacy …
treatment for type 2 diabetes, yet its mechanisms of action and variability in terms of efficacy …
Leptin resistance and diet-induced obesity: central and peripheral actions of leptin
Obesity is a chronic disease that represents one of the most serious global health burdens
associated to an excess of body fat resulting from an imbalance between energy intake and …
associated to an excess of body fat resulting from an imbalance between energy intake and …
[HTML][HTML] Mechanisms of glucose absorption in the small intestine in health and metabolic diseases and their role in appetite regulation
LV Gromova, SO Fetissov, AA Gruzdkov - Nutrients, 2021 - mdpi.com
The worldwide prevalence of metabolic diseases such as obesity, metabolic syndrome and
type 2 diabetes shows an upward trend in recent decades. A characteristic feature of these …
type 2 diabetes shows an upward trend in recent decades. A characteristic feature of these …
The antidiabetic potential of quercetin: underlying mechanisms
The dramatic increase in modern lifestyle diseases such as cancer, cardiovascular diseases
and diabetes has renewed researchers' interest to explore nature as a source of novel …
and diabetes has renewed researchers' interest to explore nature as a source of novel …
[HTML][HTML] Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation
Intestinal Paneth cells modulate innate immunity and infection. In Crohn's disease, genetic
mutations together with environmental triggers can disable Paneth cell function. Here, we …
mutations together with environmental triggers can disable Paneth cell function. Here, we …
[HTML][HTML] The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing
PV Röder, KE Geillinger, TS Zietek, B Thorens… - PloS one, 2014 - journals.plos.org
Intestinal glucose absorption is mediated by SGLT1 whereas GLUT2 is considered to
provide basolateral exit. Recently, it was proposed that GLUT2 can be recruited into the …
provide basolateral exit. Recently, it was proposed that GLUT2 can be recruited into the …
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
K Zhou, SW Yee, EL Seiser, N Van Leeuwen… - Nature …, 2016 - nature.com
Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its
mechanism of action remains unclear. Here the Metformin Genetics (MetGen) Consortium …
mechanism of action remains unclear. Here the Metformin Genetics (MetGen) Consortium …
[HTML][HTML] Regulation of intestinal glucose absorption by ion channels and transporters
L Chen, B Tuo, H Dong - Nutrients, 2016 - mdpi.com
The absorption of glucose is electrogenic in the small intestinal epithelium. The major route
for the transport of dietary glucose from intestinal lumen into enterocytes is the Na+/glucose …
for the transport of dietary glucose from intestinal lumen into enterocytes is the Na+/glucose …