[HTML][HTML] Mechanisms of epigenetic regulation by C. elegans nuclear RNA interference pathways
U Seroussi, C Li, AE Sundby, TL Lee… - Seminars in Cell & …, 2022 - Elsevier
RNA interference (RNAi) is a highly conserved gene regulatory phenomenon whereby
Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense …
Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense …
Chromosome organization in 4D: insights from C. elegans development
Eukaryotic genome organization is ordered and multilayered, from the nucleosome to
chromosomal scales. These layers are not static during development, but are remodeled …
chromosomal scales. These layers are not static during development, but are remodeled …
[HTML][HTML] Transmission of chromatin states across generations in C. elegans
I Özdemir, FA Steiner - Seminars in Cell & Developmental Biology, 2022 - Elsevier
Epigenetic inheritance refers to the transmission of phenotypes across generations without
affecting the genomic DNA sequence. Even though it has been documented in many …
affecting the genomic DNA sequence. Even though it has been documented in many …
DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans
LI Lascarez-Lagunas, E Herruzo, A Grishok… - PLoS …, 2020 - journals.plos.org
Epigenetic modifiers are emerging as important regulators of the genome. However, how
they regulate specific processes during meiosis is not well understood. Methylation of …
they regulate specific processes during meiosis is not well understood. Methylation of …
Male-specific behavioral and transcriptomic changes in aging C. elegans neurons
Aging is a complex biological process with sexually dimorphic aspects. Although cognitive
aging of Caenorhabditis elegans hermaphrodites has been studied, less is known about …
aging of Caenorhabditis elegans hermaphrodites has been studied, less is known about …
The H3K79 methylase DOT1, unreported in photosynthetic plants, exists in Alexandrium pacificum and participates in its growth regulation
Z Zhu, J Qi, Y Liu, Z Sui - Marine Pollution Bulletin, 2023 - Elsevier
Alexandrium pacificum is one of the typical toxic dinoflagellate species leading to harmful
algal blooms (HABs). Histone modifications play key roles in many cellular events, but little …
algal blooms (HABs). Histone modifications play key roles in many cellular events, but little …
[HTML][HTML] DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin
GP Sepulveda, ES Gushchanskaia, A Mora-Martin… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The proto-oncogene c-MYC is a key representative of the MYC transcription factor network
regulating growth and metabolism. MML-1 (Myc-and Mondo-like) is its homolog in C …
regulating growth and metabolism. MML-1 (Myc-and Mondo-like) is its homolog in C …
[HTML][HTML] DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation
T Liontis, K Verma, A Grishok - BBA advances, 2023 - Elsevier
Methylation of histone H3 at lysine 79 (H3K79) is conserved from yeast to humans and is
accomplished by Dot1 (disruptor of telomeric silencing-1) methyltransferases. The C …
accomplished by Dot1 (disruptor of telomeric silencing-1) methyltransferases. The C …
Male-specific features of C. elegans neuronal aging
Aging is a complex biological process, with sexually dimorphic aspects. For example, men
and women differ in their vulnerabilities in cognitive decline, suggesting biological sex may …
and women differ in their vulnerabilities in cognitive decline, suggesting biological sex may …
[HTML][HTML] The proline-rich domain of MML-1 is biologically important but not required for localization to target promoters
The only representative of the MYC superfamily transcription factors in C. elegans, MML-1
(Myc and Mondo-like 1), was shown to promote extended lifespan in a variety of models and …
(Myc and Mondo-like 1), was shown to promote extended lifespan in a variety of models and …