Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Bacteria possess an extraordinary repertoire of cell envelope glycans that have critical
physiological functions. Pathogenic bacteria have glycans that are essential for growth and …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Membrane lipid homeostasis is a vital facet of bacterial cell physiology. For decades,
research in bacterial lipid synthesis was largely confined to the Escherichia coli model …

Tuberculosis (TB) remains the second most common cause of death due to a single
infectious agent. The cell envelope of Mycobacterium tuberculosis (Mtb), the causative agent …

Inositol lipids are ubiquitous in eukaryotes and have finely tuned roles in cellular signalling
and membrane homoeostasis. In Bacteria, however, inositol lipid production is relatively …

Lipomannan (LM) and lipoarabinomannan (LAM) are mycobacterial glycolipids containing a
long mannose polymer. While they are implicated in immune modulations, the significance …

Membrane-associated GT-B glycosyltransferases (GTs) comprise a large family of enzymes
that catalyze the transfer of a sugar moiety from nucleotide-sugar donors to a wide range of …

Protected from host immune attack and antibiotic penetration by their unique cell envelope,
mycobacterial pathogens cause devastating human diseases such as tuberculosis …

Actinobacteria is a group of diverse bacteria. Most species in this class of bacteria are
filamentous aerobes found in soil, including the genus Streptomyces perhaps best known for …