The human virome: assembly, composition and host interactions

G Liang, FD Bushman - Nature Reviews Microbiology, 2021 - nature.com
The human body hosts vast microbial communities, termed the microbiome. Less well
known is the fact that the human body also hosts vast numbers of different viruses …

The gut virome: A new microbiome component in health and disease

Z Cao, N Sugimura, E Burgermeister, MP Ebert… - …, 2022 - thelancet.com
The human gastrointestinal tract harbours an abundance of viruses, collectively known as
the gut virome. The gut virome is highly heterogeneous across populations and is linked to …

Interferon-λ orchestrates innate and adaptive mucosal immune responses

L Ye, D Schnepf, P Staeheli - Nature Reviews Immunology, 2019 - nature.com
Type III interferon (IFN-λ) was initially thought to have functions similar to those of the type I
interferons (IFN-α and IFN-β). New findings have indicated, however, that IFN-λ has a non …

Human rhinovirus infection blocks severe acute respiratory syndrome coronavirus 2 replication within the respiratory epithelium: implications for COVID-19 …

K Dee, DM Goldfarb, J Haney, JAR Amat… - The Journal of …, 2021 - academic.oup.com
Virus-virus interactions influence the epidemiology of respiratory infections. However, the
impact of viruses causing upper respiratory infections on severe acute respiratory syndrome …

Prospective virome analyses in young children at increased genetic risk for type 1 diabetes

K Vehik, KF Lynch, MC Wong, X Tian, MC Ross… - Nature medicine, 2019 - nature.com
Viruses are implicated in autoimmune destruction of pancreatic islet β cells, which results in
insulin deficiency and type 1 diabetes (T1D),,–. Certain enteroviruses can infect β cells in …

Microbiota regulation of viral infections through interferon signaling

NI Wirusanti, MT Baldridge, VC Harris - Trends in microbiology, 2022 - cell.com
The interferon (IFN) response is the major early innate immune response against invading
viral pathogens and is even capable of mediating sterilizing antiviral immunity without the …

Differential roles of interferons in innate responses to mucosal viral infections

FC Walker, PR Sridhar, MT Baldridge - Trends in Immunology, 2021 - cell.com
Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral
infection and are crucial for control of viral replication and dissemination, especially at …

Effects of intestinal fungi and viruses on immune responses and inflammatory bowel diseases

ID Iliev, K Cadwell - Gastroenterology, 2021 - Elsevier
The intestinal microbiota comprises diverse fungal and viral components, in addition to
bacteria. These microbes interact with the immune system and affect human physiology …

Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion

A Broggi, F Granucci, I Zanoni - Journal of Experimental Medicine, 2019 - rupress.org
Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to
play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique …

Fecal microbiota transplantation reverses insulin resistance in type 2 diabetes: A randomized, controlled, prospective study

Z Wu, B Zhang, F Chen, R Xia, D Zhu… - Frontiers in Cellular …, 2023 - frontiersin.org
Objectives Recent studies have shown that fecal microbiota transplantation (FMT) improved
the metabolic profiles of patients with type 2 diabetes mellitus (T2DM), yet the effectiveness …