We describe the CoMet application for large-scale epistatic Genome-Wide Association
Studies (eGWAS) and pleiotropy studies. High performance is attained by transforming the …

Aligning a set of query sequences to a set of target sequences is an important task in
bioinformatics. In this work we present merAligner, a highly parallel sequence aligner that …

Interest in discovering combinations of genetic markers from case–control studies, such as
Genome Wide Association Studies (GWAS), that are strongly associated to diseases has …

Genome-Wide Association Studies (GWASs), analyses that try to find a link between a given
phenotype (such as a disease) and genetic markers, have been growing in popularity in the …

Epistasis, the interaction between genes, has become a major topic in molecular and
quantitative genetics. It is believed that these interactions play a significant role in genetic …

Genome-wide association studies are performed to correlate a number of diseases and
other physical or even psychological conditions (phenotype) with substitutions of …

The substitution of nucleotides at specific positions in the genome of a population, known as
single-nucleotide polymorphisms (SNPs), has been correlated with a number of important …

The investigation of highly-efficient parallel algorithms targeting modern heterogeneous
systems can provide bioinformaticians new mechanisms to find relations between genetics …

Epistasis detection is a fundamental application in the areas of bioinformatics and
biomedicine, providing important insights regarding the relationship between the human …

The growth of next-generation sequencing (NGS) datasets poses a challenge to the
alignment of reads to reference genomes in terms of alignment quality and execution speed …