Highlights•Oral route of administration is the preferred route for drug delivery.•Dosage form
designing plays an essential role in oral peptide delivery.•Preclinical and clinical aspects of …

Maintaining homeostasis is central to organismal health. Deviation is detected by a variety of
sensors that react to alarm signals arising from injury, infection, and other inflammatory …

Dystrophic epidermolysis bullosa (DEB) is a blistering skin disease caused by mutations in
the gene COL7A1 encoding collagen VII. DEB can be inherited as recessive DEB (RDEB) or …

Background: Mutations in the human desmin gene cause myopathies and
cardiomyopathies. This study aimed to elucidate molecular mechanisms initiated by the …

Epidermolysis bullosa simplex (EBS) is a group of inherited keratinopathies that, in most
cases, arise due to mutations in keratins and lead to intraepidermal ruptures. The cellular …

Epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of
mechanobullous diseases characterized by non-scarring blisters and erosions on the skin …

The understanding of monogenetic disorders of cornification, including the group of
diseases called ichthyoses, has expanded greatly in recent years. Studies of the aetiology of …

Plectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein.
Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped …

During wound healing, cells have a high rate of protein synthesis and many proteins need to
be folded post‐translationally to function, which occurs in the endoplasmic reticulum (ER). In …

Subclinical doses of LPS (SD-LPS) are known to cause low-grade inflammatory activation of
monocytes, which could lead to inflammatory diseases including atherosclerosis and …