Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

The field of autoimmune neurology is rapidly evolving, and recent discoveries have
advanced our understanding of disease aetiologies. In this article, we review the key …

The mechanisms underlying the chronicity of autoimmune diseases of the central nervous
system (CNS) are largely unknown. In particular, it is unclear whether tissue-resident …

The numerous influenza infections that occur every year present a major public health
problem. Influenza vaccines are important for the prevention of the disease; however, their …

Abstract Background Narcolepsy type 1 (NT1) is a chronic disorder characterized by
pathological daytime sleepiness and cataplexy due to the disappearance of orexin …

The orexin system consists of the peptide transmitters orexin-A and-B and the G protein-
coupled orexin receptors OX 1 and OX 2. Orexin receptors are capable of coupling to all four …

Summary Narcolepsy type 1 (NT1) is a sleep-wake disorder in which people typically
experience excessive daytime sleepiness, cataplexy and other sleep-wake disturbances …

In the wake of the A/California/7/2009 H1N1 influenza pandemic vaccination campaigns in
2009-2010, an increased incidence of the chronic sleep-wake disorder narcolepsy was …

Narcolepsy type 1 (NT1) is an uncommon, persistent sleep disorder distinguished by
significant daytime sleepiness, episodes of cataplexy, and irregularities in rapid eye …

The mammalian central nervous system (CNS) contains a vibrant community of resident
adaptive immune cells at homeostasis. Among these are memory CD8+ and CD4+ T cells …