Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is the most widely
used herbicide in the world. It can persist in the environment for days or months, and its …

Introduction: Demyelinating diseases of the central nervous system (CNS) comprise a group
of neurological disorders characterized by progressive (and eventually irreversible) loss of …

Mitochondrial dysfunction in neurons has recently become a promising therapeutic target for
Alzheimer's disease (AD). Regulation of dysfunctional mitochondria through multiple …

Destruction of oligodendrocytes and myelin sheaths in cortical gray matter profoundly alters
neural activity and is associated with cognitive disability in multiple sclerosis (MS). Myelin …

This article describes commonly used experimental and clinical biomarkers of neuronal
injury and neurodegeneration for the evaluation of neuropathology and monitoring of …

A lack of stratification methods in patients with amyotrophic lateral sclerosis (ALS) is likely
implicated in therapeutic failures. Regional diversities and pathophysiological abnormalities …

Hippocampal microglia are vulnerable to the effects of aging, displaying a primed phenotype
and hyper-responsiveness to various stimuli. We have previously shown that short-term high …

Growing data from human and animal studies indicate the beneficial effects of exercise on
several clinical outcomes in patients with multiple sclerosis (MS), an autoimmune …

Theiler's murine encephalomyelitis virus (TMEV), a naturally occurring, enteric pathogen of
mice is a Cardiovirus of the Picornaviridae family. Low neurovirulent TMEV strains such as …

Why layers II/III of entorhinal cortex (EC) deteriorate in advance of other regions during the
earliest stages of Alzheimer's disease is poorly understood. Failure of retrograde trophic …