Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

Life expectancy has increased substantially over the last 150 years. Yet this means that now
most people also spend a greater length of time suffering from various age-associated …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

We use a genome-wide association of 1 million parental lifespans of genotyped subjects
and data on mortality risk factors to validate previously unreplicated findings near CDKN2B …

Human longevity correlates with socio-economic status, and there is evidence that
educational attainment increases human lifespan. However, to inform meaningful health …

Survival to extreme ages clusters within families. However, identifying genetic loci conferring
longevity and low morbidity in such longevous families is challenging. There is debate …

Human longevity is a complex trait, and to disentangle its basis has a great theoretical and
practical consequences for biomedicine. The genetics of human longevity is still poorly …

The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …

Abstract Background The American Heart Association introduced the Life's Simple 7
initiative to improve cardiovascular health by modifying cardiovascular risk factors and …

Human ageing is a complex, multifactorial process characterised by physiological damage,
increased risk of age-related diseases and inevitable functional deterioration. As the …