Chlamydia trachomatis: the persistent pathogen

SS Witkin, E Minis, A Athanasiou, J Leizer… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterium whose only natural host is
humans. Although presenting as asymptomatic in most women, genital tract chlamydial …

Chlamydial persistence: beyond the biphasic paradigm

RJ Hogan, SA Mathews, S Mukhopadhyay… - Infection and …, 2004 - Am Soc Microbiol
The chlamydiae are an evolutionarily distinct group of eubacteria sharing an obligate
intracellular lifestyle and a unique developmental cycle that has been well characterized …

Mechanisms of host cell exit by the intracellular bacterium Chlamydia

K Hybiske, RS Stephens - Proceedings of the national …, 2007 - National Acad Sciences
The mechanisms that mediate the release of intracellular bacteria from cells are poorly
understood, particularly for those that live within a cellular vacuole. The release pathway of …

Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis

RJ Belland, G Zhong, DD Crane… - Proceedings of the …, 2003 - National Acad Sciences
Chlamydia trachomatis is one of the most common bacterial pathogens and is the etiological
agent of debilitating sexually transmitted and ocular diseases in humans. The organism is …

Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming

S Koster, RK Gurumurthy, N Kumar, PG Prakash… - Nature …, 2022 - nature.com
Coinfections with pathogenic microbes continually confront cervical mucosa, yet their
implications in pathogenesis remain unclear. Lack of in-vitro models recapitulating cervical …

Immunity to murine chlamydial genital infection

RP Morrison, HD Caldwell - Infection and immunity, 2002 - Am Soc Microbiol
Chlamydia trachomatis sexually transmitted infections cause considerable morbidity and
socioeconomic burden worldwide, despite significant advances in our understanding of the …

Illuminating the evolutionary history of chlamydiae

M Horn, A Collingro, S Schmitz-Esser, CL Beier… - Science, 2004 - science.org
Chlamydiae are the major cause of preventable blindness and sexually transmitted disease.
Genome analysis of a chlamydia-related symbiont of free-living amoebae revealed that it is …

Engineering of obligate intracellular bacteria: progress, challenges and paradigms

EE McClure, ASO Chávez, DK Shaw… - Nature Reviews …, 2017 - nature.com
It is estimated that approximately one billion people are at risk of infection with obligate
intracellular bacteria, but little is known about the underlying mechanisms that govern their …

Metabolic host responses to infection by intracellular bacterial pathogens

W Eisenreich, J Heesemann, T Rudel… - Frontiers in cellular and …, 2013 - frontiersin.org
The interaction of bacterial pathogens with mammalian hosts leads to a variety of
physiological responses of the interacting partners aimed at an adaptation to the new …

Antibiotic resistance in Chlamydiae

KM Sandoz, DD Rockey - Future microbiology, 2010 - Taylor & Francis
There are few documented reports of antibiotic resistance in Chlamydia and no examples of
natural and stable antibiotic resistance in strains collected from humans. While there are …