The most recently discovered PTEN tumor suppressor gene has been found to be defective
in a large number of human cancers. In addition, germ-line mutations in PTEN result in the …

The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central
controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in …

The remit of this guideline is to collate and propose evidence-based guidelines for the
diagnosis and management of uterine cancer. This document covers all uterine cancers of …

PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and
the cytoskeletal protein tensin. mPTEN-mutant mouse embryos display regions of increased …

PTEN is among the most frequently inactivated tumour suppressor genes in sporadic
cancer. PTEN has dual protein and lipid phosphatase activity, and its tumour suppressor …

Since their discovery, protein tyrosine phosphatases have been speculated to play a role in
tumor suppression because of their ability to antagonize the growth-promoting protein …

Background: PTEN tumor suppressor gene mutations are the most frequent genetic lesions
in endometrial adenocarcinomas of the endometrioid subtype. Testing the hypothesis that …

Genetic alterations targeting the PTEN tumor suppressor gene are among the most
frequently noted somatic mutations in human cancers. Such lesions have been noted in …

Pten/Mmac1+/− heterozygous mice exhibited neoplasms in multiple organs including the
endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type …

Abstract PTEN, on 10q23. 3, encodes a major lipid phosphatase which signals down the
phosphoinositol‐3‐kinase/Akt pathway and effects G1 cell cycle arrest and apoptosis …