Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide.
HCC patients are commonly diagnosed at an advanced stage, for which highly effective …

Adipose tissue develops lipids, aberrant adipokines, chemokines, and pro-inflammatory
cytokines as a consequence of the low-grade systemic inflammation that characterizes …

Abstract Background Tumor-associated macrophages (TAMs), which form a large part of the
tumor microenvironment, are normally regulated by metabolic reprogramming. However, the …

Background Hepatocellular carcinoma (HCC) cells-secreted exosomes (exo) could
stimulate M2 macrophage polarization and promote HCC progression, but the related …

Background: The competing endogenous RNAs (ceRNAs) hypothesis has received
increasing attention as a novel explanation for tumorigenesis and cancer progression …

Immune‐related genes (IRGs) have been identified as critical drivers of the initiation and
progression of hepatocellular carcinoma (HCC). This study is aimed at constructing an IRG …

Background Alpha-fetoprotein (AFP) is the most important diagnostic and prognostic index
of hepatocellular carcinoma (HCC). AFP-positive HCC can be easily diagnosed based on …

Accumulating evidence has emerged revealing that noncoding RNAs (ncRNAs) play
essential roles in the occurrence and development of hepatocellular carcinoma (HCC) …

The tumor microenvironment (TME) is a well-recognized system that plays an essential role
in tumor initiation, development, and progression. Intense intercellular communication …

The current situation of hepatocellular carcinoma (HCC) management is challenging due to
its high incidence, mortality, recurrence and metastasis. Recent advances in gene genetic …