Development of a new affinity maturation protocol for the construction of an internalizing anti-nucleolin antibody library

R Ribeiro, JN Moreira, J Goncalves - Scientific Reports, 2024 - nature.com
Over the last decades, monoclonal antibodies have substantially improved the treatment of
several conditions. The continuous search for novel therapeutic targets and improvements in …

A viral vaccine design harnessing prior BCG immunization confers protection against Ebola virus

TW Ng, W Furuyama, AS Wirchnianski… - Frontiers in …, 2024 - frontiersin.org
Previous studies have demonstrated the efficacy and feasibility of an anti-viral vaccine
strategy that takes advantage of pre-existing CD4+ helper T (Th) cells induced by …

Novel Strategy of Antibody Affinity Maturation and Enhancement of Nucleolin‐Mediated Antibody‐Dependent Cellular Cytotoxicity Against Triple‐Negative Breast …

R Ribeiro, JMB Vítor, A Voronovska… - Biotechnology …, 2025 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is a clinically aggressive subtype of breast cancer that
remains an unmet medical need. Because TNBC cells do not express the most common …

Reconstruction of a polyclonal ADCC antibody repertoire from an HIV-1 non-transmitting mother

ZA Yaffe, S Ding, K Sung, V Chohan, L Marchitto… - Iscience, 2023 - cell.com
Human natural history and vaccine studies support a protective role of antibody dependent
cellular cytotoxicity (ADCC) activity against many infectious diseases. One setting where this …

Complementary Roles of Antibody Heavy and Light Chain Somatic Hypermutation in Conferring Breadth and Potency to the HIV-1-Specific CAP256-VRC26 bNAb …

D Sacks, K Wiehe, L Morris, PL Moore - Journal of virology, 2022 - Am Soc Microbiol
Some HIV-infected people develop broadly neutralizing antibodies (bNAbs) that block many
diverse, unrelated strains of HIV from infecting target cells and, through passive …

[图书][B] Evaluating the Impact of Antibody Epitope and Function on HIV-1 Vertical Transmission

ZA Yaffe - 2023 - search.proquest.com
Despite significant advances in scientific research and the advent of treatment and
prevention strategies over the past several decades, the HIV/AIDS pandemic continues to …

[图书][B] Modeling the HIV Genetic Bottleneck in vitro

TA Caldwell III - 2023 - search.proquest.com
As of the year 2023, there has yet to be developed an effective prophylactic vaccine against
HIV-1 infection. One likely reason for prior failures in vaccine trials is that vaccines have …

[图书][B] Antibodies Associated with Control of Mycobacterium tuberculosis Infection

E Ishida - 2022 - search.proquest.com
The disease active tuberculosis (TB) annually claims 1.5 million lives worldwide and was the
deadliest infectious disease caused by a single pathogen prior to COVID-19. Moreover, 2 …

[HTML][HTML] To Fc or not Fc: An assay for the question

S Prasad - fcslaboratory.com
Shalina has a Bachelor of Science degree in Biology from the University of Washington and
has been at FCSL for two years. Shalina is currently part of the Development Team as a …

Anti-HIV Neutralizing and Non-neutralizing Antibody Functions: Relevance to Vaccine Development

MC Home - molecularcloud.org
It has now been nearly 40 years since the human immunodeficiency virus (HIV) was
discovered. Based on the CDC, an estimated 1.2 million individuals were infected with HIV …