It has long been observed that heart failure (HF) is associated with measures of systemic
inflammation. In recent years, there have been significant advancements in our …

A hallmark of cancer is the ability of tumor cells to avoid immune destruction. Activated
immune cells in tumor microenvironment (TME) secrete proinflammatory cytokines and …

Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their
involvement in acquired and innate immunity. Increasing evidence now implicates mast cells …

Gastric cancer is diagnosed in nearly one million new patients each year and it remains the
second leading cause of cancer-related deaths worldwide. Although gastric cancer …

Mast cells (MC s) are innate immune cells that are scattered in tissues throughout the
organism being particularly abundant at sites exposed to the environment such as the skin …

▪ Abstract This review focuses on recent progress in our understanding of how mast cells
can contribute to the initiation, development, expression, and regulation of acquired immune …

The versatile role of mast cells in allergy, in innate immune responses and in the regulation
of tissue homeostasis is well recognized. However, it is often not made clear that most mast …

Mast cells are well known for their involvement in allergic and anaphylactic reactions, during
which immunoglobulin E (IgE) receptor (FcɛRI) aggregation leads to exocytosis of the …

Mast cells are crucial effector cells in allergic reactions, where IgE is the best known
mechanism to trigger their degranulation and release of a vast array of allergic mediators …

Background T-cell tolerance of allergic cutaneous contact sensitivity (CS) induced in mice by
high doses of reactive hapten is mediated by suppressor cells that release antigen-specific …