Based on engineered or bacterial nucleases, the development of genome editing
technologies has opened up the possibility of directly targeting and modifying genomic …

Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

Dysfunction of pancreatic δ cells contributes to the etiology of diabetes. Despite their
important role, human δ cells are scarce, limiting physiological studies and drug discovery …

Diabetes mellitus is a pandemic metabolic disorder that results from either the autoimmune
destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is …

Nanomedicine could improve the treatment of diabetes by exploiting various therapeutic
mechanisms through the use of suitable nanoformulations. For example, glucose-sensitive …

Studies on diabetes have long been hampered by a lack of authentic disease models that,
ideally, should be unlimited and able to recapitulate the abnormalities involved in the …

Maturity-onset diabetes of the young (MODY) is a genetically heterogeneous group of
monogenic endocrine disorders that is characterised by autosomal dominant inheritance …

Diabetes mellitus is characterized by elevated levels of blood glucose and is ultimately
caused by insufficient insulin production from pancreatic beta cells. Different research …

Neurodegenerative diseases are prominent causes of pain, suffering, and death worldwide.
Traditional approaches modelling neurodegenerative diseases are deficient, and therefore …

Pancreatic β-cells are the only source of insulin. Disturbances in β-cell development or
function may thus result in insulin deficiency or excess, presenting as hyper-or …