Corticosteroids are critically involved in blood pressure regulation. Lack of adrenal steroids
in Addison's disease causes life-threatening hypotension, whereas glucocorticoid excess in …

A substantial proportion of patients with hypertension have a low or suppressed renin. This
phenotype of low-renin hypertension (LRH) may be the manifestation of inherited genetic …

BACKGROUND: Lower activity of (11-beta) hydroxysteroid dehydrogenase 2 (11beta-
HSD2) classically induces hypertension by leading to an altered tetrahydrocortisol-versus …

In the adult mammal the circadian system, which allows predictive adaptation to daily
environmental changes, comprises peripheral oscillators in most tissues, commanded by the …

Context Classical apparent mineralocorticoid excess (AME) is a rare recessive disorder,
caused by severe 11β-hydroxysteroid dehydrogenase type 2 enzyme (11 β-HSD2) …

BACKGROUND Impairment in 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2)
activity results in inefficient inactivation of cortisol to cortisone, and it can trigger …

Hypertensive patients can be classified as affected by low-, normal-, or high-renin
hypertension based on plasma renin activity or direct renin concentration. 1 Low-renin …

Reduced activity of llbeta‐hydroxysteroid dehydrogenase type 2 (11beta‐HSD2) plays a
role in essential hypertension and the sensitivity of blood pressure to dietary salt …

The knowledge of the genetic bases of hypertension has improved over the last decade; this
area of research has high priority due to the high incidence of hypertension and its impact …

The interconversion of active and inactive corticosteroids–cortisol and cortisone,
respectively, in humans–is modulated by isozymes of 11β-hydroxysteroid dehydrogenase …