Nitric oxide (NO) is one of the critical components of the vasculature, regulating key
signaling pathways in health. In macrovessels, NO functions to suppress cell inflammation …

Recent advances provide evidence that the cellular signalling pathway comprising the
ligand-receptor duo of thrombospondin-1 (TSP1) and CD47 is involved in mediating a range …

Mice devoid of T, B, and natural killer (NK) cells distinguish between self and allogeneic
nonself despite the absence of an adaptive immune system. When challenged with an …

Vascular endothelial cells line the inner surface of the entire cardiovascular system as a
single layer and are involved in an impressive array of functions, ranging from the regulation …

Heart and kidney failure often co-exist and confer high morbidity and mortality. The complex
bi-directional nature of heart and kidney dysfunction is referred to as cardiorenal syndrome …

Background Impaired generation and signaling of nitric oxide (NO) contribute substantially
to cardiovascular (CV) risk (CVR) associated with hypertension, hyperlipidemia, and …

Thrombospondin-1 (TSP-1) is a large matricellular glycoprotein known to be overexpressed
within tumor stroma in several cancer types. While mainly considered as an endogenous …

Senescent cells withdraw from the cell cycle and do not proliferate. The prevalence of
senescent compared to normally functioning parenchymal cells increases with age …

Aims Hypoxic conditions stimulate pulmonary vasoconstriction and vascular remodelling,
both pathognomonic changes in pulmonary arterial hypertension (PAH). The secreted …

Ischemia is the underlying mechanism in a wide variety of acute and persistent pathologies.
As such, understanding the fine intracellular events occurring during (and after) the …