Metabolic modeling to interrogate microbial disease: a tale for experimentalists
The explosion of microbiome analyses has helped identify individual microorganisms and
microbial communities driving human health and disease, but how these communities …
microbial communities driving human health and disease, but how these communities …
Deciphering the metabolic capabilities of Bifidobacteria using genome-scale metabolic models
Bifidobacteria, the initial colonisers of breastfed infant guts, are considered as the key
commensals that promote a healthy gastrointestinal tract. However, little is known about the …
commensals that promote a healthy gastrointestinal tract. However, little is known about the …
Overcoming selection bias in synthetic lethality prediction
Motivation Synthetic lethality (SL) between two genes occurs when simultaneous loss of
function leads to cell death. This holds great promise for developing anti-cancer therapeutics …
function leads to cell death. This holds great promise for developing anti-cancer therapeutics …
[图书][B] An introduction to computational systems biology: systems-level modelling of cellular networks
K Raman - 2021 - taylorfrancis.com
This book delivers a comprehensive and insightful account of applying mathematical
modelling approaches to very large biological systems and networks—a fundamental aspect …
modelling approaches to very large biological systems and networks—a fundamental aspect …
Understanding flux switching in metabolic networks through an analysis of synthetic lethals
SM Narasimha, T Malpani, OS Mohite… - npj Systems Biology …, 2024 - nature.com
Biological systems are robust and redundant. The redundancy can manifest as alternative
metabolic pathways. Synthetic double lethals are pairs of reactions that, when deleted …
metabolic pathways. Synthetic double lethals are pairs of reactions that, when deleted …
Understanding flux switching in metabolic networks through an analysis of synthetic lethals
Biological systems are extremely robust and exhibit high levels of redundancy for multiple
cellular functions. Some of this redundancy manifests as alternative pathways in …
cellular functions. Some of this redundancy manifests as alternative pathways in …
Towards the Integration of Metabolic Network Modelling and Machine Learning for the Routine Analysis of High-Throughput Patient Data
The decreasing cost of high-throughput technologies allows to consider their use in
healthcare and medicine. To prepare for this upcoming revolution, the community is …
healthcare and medicine. To prepare for this upcoming revolution, the community is …