Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This
progressive hearing impairment leads to social isolation and is also associated with …

Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …

Summary The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for
sporadic Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in …

Age-related hearing impairment (ARHI) is the most common sensory impairment in the
aging population; a third of individuals are affected by disabling hearing loss by the age of …

Waardenburg syndrome (WS) is an auditory-pigmentary disorder that exhibits varying
combinations of sensorineural hearing loss and abnormal pigmentation of the hair and skin …

Mental disorders represent common brain diseases characterized by substantial
impairments of social and cognitive functions. The neurobiological causes and mechanisms …

Hearing loss (HL), or deafness in its most severe form, affects an estimated 28 and 22.5
million Americans and Europeans, respectively. The numbers are higher in regions such as …

Although the basic principles underlying the function of the peripheral auditory system have
been known for many years, the molecules required for hearing have hitherto remained …

Background Identification of genes responsible for medically important traits is a major
challenge in human genetics. Due to the genetic heterogeneity of hearing loss, targeted …

Inner ear hair cells detect sound through deflection of mechanosensory stereocilia. Each
stereocilium is supported by a paracrystalline array of parallel actin filaments that are …