Tumor-associated carbohydrate antigens (TACA) result from the aberrant glycosylation that
is seen with transformation to a tumor cell. The carbohydrate antigens that have been found …

Dendrimers are branched structures and represent a fast growing field covering many areas
of chemistry. Various types of dendrimers differing in composition and structure are …

Molecularly defined synthetic vaccines capable of inducing both antibodies and cellular anti-
tumor immune responses, in a manner compatible with human delivery, are limited. Few …

Background Glyco-lipopeptides, a form of lipid-tailed glyco-peptide, are currently under
intense investigation as B-and T-cell based vaccine immunotherapy for many cancers …

Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed
and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our …

Degeneracy of recognition of antigen by the immune system is being used as an argument
that the self–nonself discrimination cannot be a property of the specificity of its antigen …

Introduction Because of its restricted distribution in normal tissues and its high expression on
tumors of neuroectodermal origin, GD2 ganglioside is an excellent target for active specific …

Phage display technology is an emerging drug discovery tool. Using that approach, short
peptides that mimic part of a carbohydrate's conformation are selected by screening a …

Abstract The L2/HNK‐1 carbohydrate is carried by many neural recognition molecules and
is involved in neural cell interactions during development, regeneration in the peripheral …

The immune system responds efficiently to bacteria, viruses and other agents however, the
immune response to cancers is not as effective. In most cases other than specific genetic …