HIV-1 infection typically results from the transmission of a single viral variant, the
transmitted/founder (T/F) virus. Studies of these HIV-1 variants provide critical information …

Transmission of HIV-1 results in the establishment of a new infection, typically starting from a
single virus particle. That virion replicates to generate viremia and persistent infection in all …

To understand the high variability of the asymptomatic interval between primary human
immunodeficiency virus type 1 (HIV-1) infection and the development of AIDS, we studied …

Reports of cerebral dysfunction in chronic hepatitis C virus (HCV) infection have led to the
suggestion that HCV may infect the central nervous system (CNS). We used reverse …

The ultimate success of strategies to prevent sexual transmission of HIV depends, in part, on
a better understanding of the virological and immunological mechanisms that define sexual …

Studies on human immunodeficiency virus type 1 (HIV-1) diversity are critical for
understanding viral pathogenesis and the emergence of immune escape variants and for …

The predominant mode of HIV-1 infection is heterosexual transmission, where a genetic
bottleneck is imposed on the virus quasispecies. To probe whether limited genetic diversity …

Differences in the composition of the hepatitis C virus (HCV) quasispecies between plasma
and blood mononuclear cells (BMC) strongly suggest that BMCs support viral replication …

One of the most important genetic factors known to affect the rate of disease progression in
HIV-infected individuals is the genotype at the Class I Human Leukocyte Antigen (HLA) …

The V3 loop of the HIV-1 Env protein is the primary determinant of viral coreceptor usage,
whereas the V1V2 loop region is thought to influence coreceptor binding and participate in …