Studies with temporal or spatial resolution are crucial to understand the molecular dynamics
and spatial dependencies underlying a biological process or system. With advances in high …

Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …

Spatially resolved genomic technologies have allowed us to study the physical organization
of cells and tissues, and promise an understanding of local interactions between cells …

Abstract Space biology research aims to understand fundamental spaceflight effects on
organisms, develop foundational knowledge to support deep space exploration and …

Identifying spatially variable genes (SVGs) is crucial for understanding the spatiotemporal
characteristics of diseases and tissue structures, posing a distinctive challenge in spatial …

A key challenge of analyzing data from high-resolution spatial profiling technologies is to
suitably represent the features of cellular neighborhoods or niches. Here we introduce the …

Neurodegenerative diseases affect millions of people worldwide and there are currently no
cures. Two types of common neurodegenerative diseases are Alzheimer's (AD) and …

Individual cells within an otherwise genetically homogenous population constantly undergo
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …

With the aid of recent efficient and prior knowledge-free machine learning (ML) algorithms,
extraordinary mechanical properties such as negative Poisson's ratio have extensively …

Recently developed technologies to generate single-cell genomic data have made a
revolutionary impact in the field of biology. Multi-omics assays offer even greater …