Cancer elimination in humans can be achieved with immunotherapy that relies on T
lymphocyte-mediated recognition of tumor antigens. Several types of these antigens have …

The study of tumour-specific antigens (TSAs) as targets for antitumour therapies has
accelerated within the past decade. The most commonly studied class of TSAs are those …

In vitro transcribed (IVT) mRNA has recently come into focus as a potential new drug class to
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …

The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

The ability of mammals to mount adaptive immune responses culminating with the
establishment of immunological memory is predicated on the ability of the mature T cell …

Extensive tumour inflammation, which is reflected by high levels of infiltrating T cells and
interferon-γ (IFNγ) signalling, improves the response of patients with melanoma to …

▪ Abstract The conversion of exogenous and endogenous proteins into immunogenic
peptides recognized by T lymphocytes involves a series of proteolytic and other enzymatic …

mRNA is the central molecule of all forms of life. It is generally accepted that current life on
Earth descended from an RNA world. mRNA, after its first therapeutic description in 1992 …

Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of
protein-coding genes in non-canonical reading frames and translation of allegedly non …

Both infectious viral diseases and cancer have historically been some of the most common
causes of death worldwide. The COVID-19 pandemic is a decidedly relevant example of the …