Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
Mutations in BRCA1 or BRCA2 (BRCA) is synthetic lethal with poly (ADP-ribose)
polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded …
polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded …
Revisiting the BRCA-pathway through the lens of replication gap suppression:“Gaps determine therapy response in BRCA mutant cancer”
SB Cantor - DNA repair, 2021 - Elsevier
The toxic lesion emanating from chemotherapy that targets the DNA was initially debated,
but eventually the DNA double strand break (DSB) ultimately prevailed. The reasoning was …
but eventually the DNA double strand break (DSB) ultimately prevailed. The reasoning was …
Replication gaps underlie BRCA deficiency and therapy response
NJ Panzarino, JJ Krais, K Cong, M Peng, M Mosqueda… - Cancer research, 2021 - AACR
Defects in DNA repair and the protection of stalled DNA replication forks are thought to
underlie the chemosensitivity of tumors deficient in the hereditary breast cancer genes …
underlie the chemosensitivity of tumors deficient in the hereditary breast cancer genes …
S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy
Immune checkpoint blockade (ICB) is a powerful approach for cancer therapy although good
responses are only observed in a fraction of cancer patients. Breast cancers caused by …
responses are only observed in a fraction of cancer patients. Breast cancers caused by …
[HTML][HTML] Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel
Cancer growth is usually accompanied by metastasis which kills most cancer patients. Here
we aim to study the effect of cisplatin at different doses on breast cancer growth and …
we aim to study the effect of cisplatin at different doses on breast cancer growth and …
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer
(TNBC), which is a refractory disease due to its non-responsiveness to current clinical …
(TNBC), which is a refractory disease due to its non-responsiveness to current clinical …
Cullin-5 deficiency orchestrates the tumor microenvironment to promote mammary tumor development through CREB1-CCL2 signaling
Breast cancer–associated gene 1 (Brca1) deficiency induces the onset of breast cancer
formation, accompanied with extensive genetic alterations. Here, we used both the sleeping …
formation, accompanied with extensive genetic alterations. Here, we used both the sleeping …
Immune Cell Contribution to Mammary Gland Development
R Vickers, W Porter - Journal of Mammary Gland Biology and Neoplasia, 2024 - Springer
Postpartum breast cancer (PPBC) is a unique subset of breast cancer, accounting for nearly
half of the women diagnosed during their postpartum years. Mammary gland involution is …
half of the women diagnosed during their postpartum years. Mammary gland involution is …
Physiological DNA damage promotes functional endoreplication of mammary gland alveolar cells during lactation
R Molinuevo, J Menendez, K Cadle, N Ariqat… - Nature …, 2024 - nature.com
Lactation insufficiency affects many women worldwide. During lactation, a large portion of
mammary gland alveolar cells become polyploid, but how these cells balance the …
mammary gland alveolar cells become polyploid, but how these cells balance the …
[HTML][HTML] Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing
Background: BRCA1 plays critical roles in mammary gland development and mammary
tumorigenesis. And loss of BRCA1 induces mammary tumors in a stochastic manner. These …
tumorigenesis. And loss of BRCA1 induces mammary tumors in a stochastic manner. These …