The enantioselective synthesis of spirocycles has long been pursued by organic chemists.
Despite their unique 3D properties and presence in several natural products, the difficulty in …

In the area of asymmetric organocatalysis, significant effort has been dedicated during the
last decade to improve the performance of emblematic catalysts such as proline, as well as …

The catalytic enantioselective assembly of spirocyclic molecules featuring a spiro quaternary
carbon stereocenter is currently of great interest because such privileged 3D structures are …

The catalytic cyclocondensation of in situ activated α, β‐unsaturated carboxylic acids was
developed. N‐heterocyclic carbenes efficiently catalyzed the generation of α, β‐unsaturated …

Isothiourea-catalyzed annulations between 2-acyl benzazoles and α, β-unsaturated acyl
ammonium intermediates are selectively tuned to form either lactam or lactone heterocycles …

α, β-Unsaturated acyl ammonium species are versatile intermediates that have been applied
in a variety of transformations including Michael additions, domino reactions and …

An enantioselective Michael addition–four‐atom ring expansion cascade reaction involving
cyclobutanones activated by a N‐aryl secondary amide group and ortho‐amino …

This review summarizes the latest developments in asymmetric domino reactions, with the
emphasis on the preparation of spiro compounds. Discussions on the stereoselectivity of the …

Spirocyclic compounds fascinate the synthetic chemists due to their privileged ring system
and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their …

While the phosphine catalysis is a powerful tool for the construction of N-heterocycles, the
phosphine-catalyzed annulations toward lactam motif are still extremely scarce. Here, we …