The adult skeleton is renewed by remodeling throughout life. Bone remodeling is a process
where osteoclasts and osteoblasts work sequentially in the same bone remodeling unit …

The biological effects of the bisphosphonates (BPs) as inhibitors of calcification and bone
resorption were first described in the late 1960s. In the 50 years that have elapsed since …

PURPOSE To provide guidance regarding best practices in the prevention and
management of medication-related osteonecrosis of the jaw (MRONJ) in patients with …

This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …

Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

The ability of bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2) to inhibit bone
resorption has been known since the 1960s, but it is only recently that a detailed molecular …

There is emerging awareness that subchondral bone remodeling plays an important role in
the development of osteoarthritis (OA). This review presents recent investigations on the …

Bone health of the elderly is a major global health concern, since about 1 in 3 women and 1
in 5 men suffer from bone loss and fractures, often called osteoporosis, in old age. Bone …

Nanoparticulate silver coatings for orthopaedic implants promise to decrease postoperative
infection rates. However, silver-induced cytotoxicity on bone cells has not been investigated …

Root amputation, extraction of a single tooth, bone loss or severe tooth mobility, and an
unclosed wound were significantly associated with increased risk of developing medication …