The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role
in regulating development and homeostasis in various tissues. The cellular processes and …

Coordinated function of the innate and adaptive arms of the immune system in vertebrates is
essential to promote protective immunity and to avoid immunopathology. The Notch …

Proteolysis is an irreversible physiological process that can result in the termination or
activation of protein function. Many transmembrane proteins that are involved in the cellular …

Activation of cells in the adaptive immune system is a highly orchestrated process dictated
by multiples cues from the innate immune system. Although the fundamental principles of …

Many advances in our understanding of the molecules that regulate the development,
differentiation and function of T cells have been made over the past few years. One …

The remarkable plasticity of CD4+ T cells allows individuals to respond to environmental
stimuli in a context‐dependent manner. A balance of CD4+ T cell subsets is critical to mount …

Differentiation of naïve T cells into effector cells is required for optimal protection against
different classes of microbial pathogen and for the development of immune memory. Recent …

Control of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and
immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not …

Differentiation of naïve T cells leads to the generation of T-cell subsets, each possessing
distinct cytokine expression profiles for serving different immune functions. Through the …