Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc), a process
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …

Histones display a wide variety of post-translational modifications, including acetylation,
methylation, and phosphorylation. These epigenetic modifications can influence chromatin …

Posttranslational modifications alter the biophysical properties of proteins and thereby
influence cellular physiology. One emerging manner by which such modifications regulate …

Cells continuously fine-tune signaling pathway proteins to match nutrient and stress levels in
their local environment by modifying intracellular proteins with O-linked N …

Metabolite sensing, a fundamental biological process, plays a key role in metabolic
signaling circuit rewiring. Hexosamine biosynthetic pathway (HBP) is a glucose metabolic …

A fundamental mechanism that all eukaryotic cells use to adapt to their environment is
dynamic protein modification with monosaccharide sugars. In humans, O-linked N …

Glioma is a rapidly growing and aggressive primary malignant tumor of the central nervous
system that can diffusely invade the brain tissue around, and the prognosis of patients is not …

O-Linked β-N-acetylglucosamine (O-GlcNAc) is an essential, dynamic monosaccharide post-
translational modification (PTM) found on serine and threonine residues of thousands of …

Unresolved hyperglycaemia, a hallmark of type 2 diabetes mellitus (T2DM), is a well
characterised manifestation of altered fuel homeostasis and our understanding of its role in …

The transport of proteins between the different cellular compartments and the cell surface is
governed by the secretory pathway. Alternatively, unconventional secretion pathways have …