Glutamatergic and GABAergic neurons in pontine central gray mediate opposing valence-specific behaviors through a global network

C Xiao, J Wei, G Zhang, C Tao, JJ Huang, L Shen… - Neuron, 2023 - cell.com
Extracting the valence of environmental cues is critical for animals' survival. How valence in
sensory signals is encoded and transformed to produce distinct behavioral responses …

Emotional Bias among Individuals at Risk for Seasonal Affective Disorder—An EEG Study during Remission in Summer

D Theódórsdóttir, Y Höller - Brain sciences, 2023 - mdpi.com
Emotional bias in attention and memory is well researched in depression. Patients with
depression prioritize processing of negative information over positive input. While there is …

Effect of plasma polyunsaturated fatty acid levels on leukocyte telomere lengths in the Singaporean Chinese population

X Chang, R Dorajoo, Y Sun, L Wang, CN Ong, J Liu… - Nutrition journal, 2020 - Springer
Background Shorter telomere length (TL) has been associated with poor health behaviors,
increased risks of chronic diseases and early mortality. Excessive shortening of telomere is …

Altered brainstem anatomy in migraine

KK Marciszewski, N Meylakh, F Di Pietro… - …, 2018 - journals.sagepub.com
Background The exact mechanisms responsible for migraine remain unknown, although it
has been proposed that changes in brainstem anatomy and function, even between attacks …

Pons to posterior cingulate functional projections predict affective processing changes in the elderly following eight weeks of meditation training

R Shao, K Keuper, X Geng, TMC Lee - EBioMedicine, 2016 - thelancet.com
Evidence indicates meditation facilitates affective regulation and reduces negative affect. It
also influences resting-state functional connectivity between affective networks and the …

[HTML][HTML] Classification of major depressive disorder using machine learning on brain structure and functional connectivity

Z Liu, NML Wong, R Shao, SH Lee, CM Huang… - Journal of Affective …, 2022 - Elsevier
Background Timely identification of the risk of having Major Depressive Disorder (MDD)
using the advanced machine learning (ML) approach has been popularized to generate …

Effects of bright light therapy on cingulate cortex dynamic functional connectivity and neurotransmitter activity in young adults with subthreshold depression

G Tang, P Chen, G Chen, Z Yang, W Ma, H Yan… - Journal of Affective …, 2025 - Elsevier
Background The neurobiological mechanisms behind the antidepressant effect of bright light
therapy (BLT) are unclear. We aimed to explore the dynamic functional connectivity (dFC) …

Amygdala–pons connectivity is hyperactive and associated with symptom severity in depression

JJ Wong, NML Wong, DHF Chang, D Qi… - Communications …, 2022 - nature.com
Abstract Knowledge of the neural underpinnings of processing sad information and how it
differs in people with depression could elucidate the neural mechanisms perpetuating sad …

[HTML][HTML] The pontine-driven somatic gaze tract contributes to affective processing in humans

JJ Wong, DHF Chang, D Qi, W Men, JH Gao, TMC Lee - Neuroimage, 2020 - Elsevier
The relevance of subcortical structures for affective processing is not fully understood.
Inspired by the gerbil retino-raphe pathway that has been shown to regulate affective …

Heavy drinking in adolescents is associated with change in brainstem microstructure and reward sensitivity

A Galinowski, R Miranda, H Lemaitre… - Addiction …, 2020 - Wiley Online Library
The cortical‐cerebellar circuit is vulnerable to heavy drinking (HD) in adults. We
hypothesized early microstructural modifications of the pons/midbrain region, containing …