Tourette's syndrome

J Jankovic - New England Journal of Medicine, 2001 - Mass Medical Soc
The French neurologist Georges Gilles de la Tourette first described this syndrome, which
consists of motor tics sometimes accompanied by uncontrollable noises or utterances …

Obsessive-compulsive disorder and its related disorders: a reappraisal of obsessive-compulsive spectrum concepts

DL Murphy, KR Timpano, MG Wheaton… - Dialogues in clinical …, 2010 - Taylor & Francis
Obsessive-compulsive disorder (OCD) is a clinical syndrome whose hallmarks are
excessive, anxiety-evoking thoughts and compulsive behaviors that are generally …

[HTML][HTML] Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia

AT Pagnamenta, E Bacchelli, MV de Jonge, G Mirza… - Biological …, 2010 - Elsevier
BACKGROUND: Autism spectrum disorders (ASDs) are characterized by social,
communication, and behavioral deficits and complex genetic etiology. A recent study of 517 …

Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive–compulsive disorder as an example of overlapping …

DL Murphy, PR Moya, MA Fox… - … of the Royal …, 2013 - royalsocietypublishing.org
Individuals with obsessive–compulsive disorder (OCD) have also been shown to have
comorbid lifetime diagnoses of major depressive disorder (MDD; rates greater than 70%) …

The genetic basis of Gilles de la Tourette Syndrome

P Paschou - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
Gilles de la Tourette Syndrome (TS) is a neuropsychiatric disorder that is caused by a likely
complex genetic basis, interacting with environmental factors. Just as multiple large scale …

A Mutation in the Inner Mitochondrial Membrane Peptidase 2-Like Gene (Immp2l) Affects Mitochondrial Function and Impairs Fertility in Mice

B Lu, C Poirier, T Gaspar, C Gratzke… - Biology of …, 2008 - academic.oup.com
The mitochondrion is involved in energy generation, apoptosis regulation, and calcium
homeostasis. Mutations in genes involved in mitochondrial processes often result in a …

Intragenic deletions affecting two alternative transcripts of the IMMP2L gene in patients with Tourette syndrome

B Bertelsen, L Melchior, LR Jensen, C Groth… - European Journal of …, 2014 - nature.com
Tourette syndrome is a neurodevelopmental disorder characterized by multiple motor and
vocal tics, and the disorder is often accompanied by comorbidities such as attention-deficit …

Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse

AJ Lawther, J Zieba, Z Fang, TM Furlong, I Conn… - Genes, 2023 - mdpi.com
Mitochondrial dysfunction is strongly associated with autism spectrum disorder (ASD) and
the Inner mitochondrial membrane protein 2-like (IMMP2L) gene is linked to autism …

Translocation breakpoint at 7q31 associated with tics: further evidence for IMMP2L as a candidate gene for Tourette syndrome

C Patel, L Cooper-Charles, DJ McMullan… - European journal of …, 2011 - nature.com
Gilles de la Tourette syndrome is a complex neuropsychiatric disorder with a strong genetic
basis. We identified a male patient with Tourette syndrome-like tics and an apparently …

From genetics to epigenetics: new perspectives in Tourette syndrome research

L Pagliaroli, B Vető, T Arányi, C Barta - Frontiers in neuroscience, 2016 - frontiersin.org
Gilles de la Tourette Syndrome (TS) is a neurodevelopmental disorder marked by the
appearance of multiple involuntary motor and vocal tics. TS presents high comorbidity rates …