Breast cancer (BC) is a devastating disease in female around the world causing significant
health care burden in both developed and developing countries. In many cases BC has …

Breast cancer is one of the most commonly diagnosed cancers around the globe and
accounts for a large proportion of fatalities in women. Despite the advancement in …

ABCB1 detoxifies cells by exporting diverse xenobiotic compounds, thereby limiting drug
disposition and contributing to multidrug resistance in cancer cells. Multiple small-molecule …

Alkaloids are nitrogen-containing natural products found in bacteria, fungi, animals, and
plants with complex and diverse structures. The widespread distribution of alkaloids along …

Antimitotics that target tubulin are among the most useful chemotherapeutic drugs, but their
clinical activity is often limited by the development of multidrug resistance. We recently …

This work examined the cytotoxic effects of colchicine on PC3 cells and elucidated the
possible underlying mechanisms of its cytotoxicity. The cells were exposed to colchicine at …

Background Targeted therapy with trastuzumab has become a mainstay for HER2-positive
breast cancer without a clear understanding of the mechanism of its action. While many …

Background Docetaxel chemotherapy in prostate cancer has a modest impact on survival.
To date, efforts to develop combination therapies have not translated into new treatments …

Targeting protein for Xenopus kinesin‑like protein 2 (TPX2) activates Aurora kinase A during
mitosis and targets its activity to the mitotic spindle, serving an important role in mitosis. It …

Abstract Pure Zr-MOFs (UiO-66) particles have been synthesized by solvothermal method.
As synthesized, UiO-66 particles are observed to have cubical shape with average particle …