Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …

A major challenge in understanding gene regulation is the unequivocal identification of
enhancer elements and uncovering their connections to genes. We present GeneHancer, a …

Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has
sparked an interest in their epigenetic regulation. Several tumor types include …

Neuroblastoma is a tumor of the peripheral sympathetic nervous system, derived from
multipotent neural crest cells (NCCs). To define core regulatory circuitries (CRCs) controlling …

Gene expression is regulated by promoters and enhancers marked by histone H3 lysine 27
acetylation (H3K27ac), which is established by the paralogous histone acetyltransferases …

Patients with cancer carry somatic sequence variants in their tumour in addition to the
germline variants in their inherited genome. Although variants in protein-coding regions …

Non-coding regions amplified beyond oncogene borders have largely been ignored. Using
a computational approach, we find signatures of significant co-amplification of non-coding …

A large number of genes associated with various cancer types contain single nucleotide
polymorphisms (SNPs). SNPs are located in gene promoters, exons, introns as well as 5' …

Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …