Randomized phase III BMT CTN trial of calcineurin inhibitor–free chronic graft-versus-host disease interventions in myeloablative hematopoietic cell transplantation for …

L Luznik, MC Pasquini, B Logan, RJ Soiffer… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE Calcineurin inhibitors (CNI) are standard components of graft-versus-host
disease (GVHD) prophylaxis after hematopoietic cell transplantation (HCT). Prior data …

Switching from salvage chemotherapy to immunotherapy in adult B-cell acute lymphoblastic leukemia

D Kegyes, C Jitaru, G Ghiaur, S Ciurea, D Hoelzer… - Blood Reviews, 2023 - Elsevier
About one-half of adults with acute B-cell lymphoblastic leukemia (B-ALL) who do not
achieve molecular complete remission or who subsequently relapse are not cured by …

The development of post-transplant cyclophosphamide: Half a century of translational team science

PV O'Donnell, RJ Jones - Blood reviews, 2023 - Elsevier
Close HLA matching of donors and recipients has been the dogma for successful allogeneic
blood or marrow transplantation (alloBMT), to limit the complications of graft-versus-host …

Relationship of donor age and relationship to outcomes of haploidentical transplantation with posttransplant cyclophosphamide

AE DeZern, C Franklin, HL Tsai, PH Imus… - Blood …, 2021 - ashpublications.org
Allogeneic blood or marrow transplantation (BMT) physicians seek to optimize all possible
variables to improve outcomes. Selectable factors include conditioning, graft-versus-host …

Post-transplant cyclophosphamide containing regimens after matched sibling, matched unrelated and haploidentical donor transplants in patients with acute …

J Sanz, JE Galimard, M Labopin, B Afanasyev… - Journal of Hematology & …, 2021 - Springer
Background There is no information on the impact of donor type in allogeneic hematopoietic
stem cell transplantation (HCT) using homogeneous graft-versus-host (GVHD) prophylaxis …

[HTML][HTML] Haploidentical donor hematopoietic cell transplantation for myelodysplastic/myeloproliferative overlap neoplasms: results from a North American collaboration

T Jain, HL Tsai, H Elmariah, P Vachhani… - …, 2023 - ncbi.nlm.nih.gov
Haploidentical donors offer a potentially readily available donor, especially for non-White
patients, for hematopoietic cell transplantation (HCT). In this North American collaboration …

Post-transplantation cyclophosphamide is associated with increased bacterial infections

C Ustun, M Chen, S Kim, JJ Auletta… - Bone marrow …, 2024 - nature.com
Post-transplant cyclophosphamide (PTCy) is increasingly used to reduce graft-versus-host
disease after hematopoietic cell transplantation (HCT); however, it might be associated with …

Philadelphia-chromosome positive acute lymphoblastic leukemia: ten frequently asked questions

I Abou Dalle, N Moukalled, J El Cheikh, M Mohty… - Leukemia, 2024 - nature.com
Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) constitutes a
distinctive cytogenetic entity associated with challenging outcomes, particularly in adult …

How to manage Philadelphia-positive acute lymphoblastic leukemia in resource-constrained settings

W Silva, E Rego - Cancers, 2023 - mdpi.com
Simple Summary Remarkable strides have been performed in the treatment of adults
diagnosed with Philadelphia-positive lymphoblastic leukemia (Ph+ ALL) through the …

Post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis with nonmyeloablative conditioning for blood or marrow transplantation for …

T Jain, HL Tsai, AE DeZern, LP Gondek… - … and cellular therapy, 2022 - Elsevier
We describe outcomes after post-transplantation cyclophosphamide and nonmyeloablative
conditioning-based allogeneic blood or marrow transplantation for myelofibrosis using …