Covering: up to early 2011 Streptomycetes and other actinobacteria are renowned as a rich
source of natural products of clinical, agricultural and biotechnological value. They are being …

Streptomyces species continue to attract attention as a source of novel medicinal
compounds. Despite a long history of studies on these microorganisms, they still have many …

RAVEN is a commonly used MATLAB toolbox for genome-scale metabolic model (GEM)
reconstruction, curation and constraint-based modelling and simulation. Here we present …

Pharmaceutically important polyketides such as avermectin are mainly produced as
secondary metabolites during the stationary phase of growth of Streptomyces species in …

Covering up to end 2015 Microbial fermentation provides an attractive alternative to
chemical synthesis for the production of structurally complex natural products. In most cases …

One of the most promising applications of synthetic biology is the biosynthesis of new drugs
from secondary metabolites. Here, we survey a wide range of strategies that control the …

Covering: 2010 to 2020 Over the last few decades, Streptomyces have been extensively
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …

The mycelial bacterium Streptomyces is a workhorse for producing natural products, serving
as a key source of drugs and other valuable chemicals. However, its complicated life cycle …

Bordbar A, Palsson BO (University of California San Diego, La Jolla, CA, USA). Using the
reconstructed genome‐scale human metabolic network to study physiology and pathology …

In microorganisms, different from primary metabolism for cellular growth, secondary
metabolism is for ecological interactions and stress responses and an important source of …